Pack FemmeUp Plenipausia x2

Many products on the market for hot flashes are soy-based. Soy showed improvements especially in Asian populations, and those benefits were attempted to be transferred to Western populations. The difference is that while those populations consume it regularly throughout their lives, we take it sporadically and isolated. This causes it to ferment differently in our microbiota and consequently we do not obtain the same benefits.

Also, while the mechanism of action of many products for hot flashes is phytoestrogenic, our ingredients act at different levels.

In 2018, the European Medicines Agency recognized the marketing of Cimicifuga racemosa (CR) as a herbal medicinal product, given its efficacy in treating vasomotor symptoms of menopause (VMS). After analyzing several studies, it was concluded that cimicifuga is an evidence-based treatment to safely and effectively treat vasomotor and psychological symptoms, whether in patients who reach menopause naturally or iatrogenically. The mechanism of action of CR is not due to its activity on estrogen receptors, but to its ability to bind and modulate key receptors of the central nervous system involved in thermoregulation, mood, and sleep (serotonin, dopamine, gamma-aminobutyric acid, opioids…). This mechanism of action explains the beneficial effects produced on climacteric symptoms and the fact that it does not interact with hormone-dependent tissues. It has been shown not to induce changes in breast tissue density, endometrial thickness, nor cause alterations in vaginal cytology.